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Replacement of injured tissue by collagen-rich fibrous connective tissue.

Preferential degeneration and death of a particular neuronal population.

Inflammation producing a relatively cell-poor watery fluid derived from plasma or mesothelial secretions.

The label is process-shaped, but the organ-specific concept may also function as a disorder; manual semantic review is required.

Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep).

Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with anoth…

Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle…

Parasomnias characterized by behavioral abnormalities that occur during the transition between wakefulness and sleep (or between sleep and wakefulnes…

Neoplastic cells arranged in broad cohesive sheets without obvious glandular or papillary differentiation.

A parasomnia characterized by a partial arousal that occurs during stage IV of non-REM sleep. Affected individuals exhibit semipurposeful behaviors s…

Language disorder that delays the mastery of oral language skills or in children who have no hearing loss or other developmental delays.

Diagnosed when there are specific deficits in an individual’s ability to perceive or process information efficiently and accurately. This disorder f…

The label is process-shaped, but the organ-specific concept may also function as a disorder; manual semantic review is required.

Primarily a pathological, laboratory or structured observational finding rather than a disease entity.

Spindle cells radiating from multiple centers in a cartwheel-like arrangement.

The label is process-shaped, but the organ-specific concept may also function as a disorder; manual semantic review is required.

Magnesium ammonium phosphate crystals with a coffin-lid morphology.

The label is process-shaped, but the organ-specific concept may also function as a disorder; manual semantic review is required.

Abuse, overuse, or misuse of a substance by its injection into a vein.

Abuse, overuse, or misuse of a substance by ingestion.

Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept…

Disorders related to substance use or abuse.

Inflammatory process dominated by neutrophils with formation of purulent exudate.

Sustained hypertension used as a ClinicalGraph target concept for pathology / differential.

Inadequate blood flow and oxygen delivery to tissues across multiple organ systems.

Tissue damage produced by sensitized T lymphocytes and their cytokines.

The label denotes a pathological biological process or mechanism, not a disease entity.

Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor…

Basophilic mineralized calcium salts deposited within tissue.

Microscopically or histochemically demonstrable copper accumulated within tissue.